Before the smallpox vaccine was made smallpox was a very serious disease that killed over 400,000,0 Europeans alone by the end of the 1700s. It was highly contagious and you get the virus by inhaling it because the people who do have it cough and breathe it so it flies out of their mouth into yours. people who get it normally die but those who don’t have a to of little scars all over their body. A guy noticed that milkmaids who got cowpox from the cows they milked never got smallpox. This was because cowpox is a nonlethal version of smallpox and so when they got cowpox it built up their antibodies that kept them from dying of smallpox. All vaccines are just nonlethal versions of the disease you are getting the vaccine for.